Rat
＊ National Institute of Infectious Diseases.
Outbred
Slc:SD
| Source | Charles River Laboratories,Inc.(U.S.A)(1968) |
| Coat color | Albino |
- Gentle, Good growth, High fertility, Large
- Use for studies: Biomedical research, Bioassays
Slc:Wistar
| Source | Institute of Medical Science,University of Tokyo(1968) |
| Coat color | Albino |
- Gentle, Good growth, High fertility, Comparatively small
- Use for studies: Biomedical research, Bioassays
Slc:Wistar/ST
| Source | Institute of Medical Science,University of Tokyo(1974) |
| Coat color | Albino |
- Gentle, Good growth, High fertility, Large
- Use for studies: Biomedical research, Bioassays
Iar:Long-Evans
| Source | Tohoku university School of Medicine(1994 or 1996) |
| Coat color | Hooded |
- Use for studies: Ophthalmology, Behavior
Inbred
F344/NSlc
| Source | Institute of Medical Science,University of Tokyo(1980) |
| Coat color | Albino |
- Gentle, Good growth, High fertility, Small
- Use for studies: Pharmacology, Long-term carcinogenicity
Arthritis
DA/Slc
| Source | Kumamoto University School of medicine(1983) This strain was produced by hysterectomy and fostering(parent:SD[GN]) in 1984 |
| Coat color | Dark Agouti |
- Use for studies: Adjuvant-induced arthritis, Collage-induced arthritis (CIA), Experimental allergic encephalomyelitis, Transplantation immunity, Diarrhea by the side effect of CTP -11 (irinotecan)
Arthritis
LEW/SsNSlc
| Source | National Cancer Institute of Health,USA(1994) |
| Coat color | c,a,h(Albino) |
- Type II collagen arthritis (Drug-induced), Autoimmunization-related cardiomyopathy
BN/SsNSlc
| Source | National Cancer Institute of Health,USA(1994) |
| Coat color | a,b,h(Brown) |
- Use for studies: Transplantation immunity, Allergy
Disease Models
Diabetes
GK/Slc
| Source | Tohoku University School of Medicine(1999) |
| Coat color | Albino |
- Use for studies: Type II diabetes mellitus (Elevation of blood glucose level; minor), Non-insulin-dependent Diabetes Mellitus (NIDDM)
Obesity
Slc:Zucker -fa/fa
| Source | Tokyo University School of Medicine(1996) |
| Gene | Leprfa |
| Coat color | Hooded |
- Obesity, Ectopic calcification
Hypertension
SHR/Izm
(Hypertensive diseases)
SHRSP/Izm(Stroke)
WKY/Izm(Control to SHR/lzm)
| Source | Breeding and supply entrusted by the Joint Research Association for Disease Models such as SHR (2000) |
| Coat color | Albino |
- Hypertension (SHR/Izm)
- Cerebrovascular disorder (SHRSP/Izm)
Hypertension
DIS/EisSlc (Dahl-lwai S)
(Salt-sensitive rat)
DIR/EisSlc (Dahl-lwai R)
(Salt-resistant rat)
| Source | These rats are bred and produced at Esai co., Ltd., and provided by SLC.(2004) |
| Coat color | Albino |
- High salt sensitive hypertension (DIS/EisSlc)
- Salt resistance (DIR/EisSlc)
- Heart failure and blood pressure-related study: Use of the exclusive feed
NASH
SHRSP5/Dmcr
| Source | Distribution of breeding production by entrusted the joint Disease Model Cooperative Research Association(DMCRA). |
- Fatty deposition of intestinal membrane artery: High fat diet (HFC) (Funabashi Farm Co.,Ltd.)
- Severe fibrosis of liver by fatty deposition
Hairlessness
HWY/Slc
(Hairless rat)
| Source | Laboratory of Experimental Animals,Yagi Memorial Park(1993) |
| Coat color | Hairless rat(Albino) |
- Use for studies: Clinic and fundamental researches of the skin, Percutaneous absorption, UV radiation, Pressure sore
- J Anat. 1997 Jul; 191: 99–106. Hair follicles of young Wistar strain hairless rats: a histological study
Transgenic(GFP)
SD-Tg
(CAG-EGFP)
(Green rat)
| Source | Genome Information Research Center,Osaka University(2002) |
- Most tissue cells express EGFP by CAG promoter and express green fluorescence (Photo ※).
The customers using the above animals with modified genes are kindly requested to comply with related laws.
Transgenic(gpt delta)
F344/NSlc-Tg
(gpt delta)
| Source | The National Institute of Health Sciences(2010) |
- Use for studies: Detection of the point and deletions mutations, Genotoxicity studies including comet assays
The customers using the above animals with modified genes are kindly requested to comply with related laws.
Transgenic(SOD1H46R)
Amyotrophic Lateral Sclerosis(ALS)
Slc:SD-Tg(SOD1H46R-4)
| Source | Tohoku Univercity(2005) |
| Coat color | Albino |
- These rats are useful for ALS pathophysiology and therapeutic research
- Progressive motor symptoms from about 24 weeks of age
- Endpoint at approximately 4 weeks from onset
- Breeding and supply entrusted by Tohoku Univercity
The customers using the above animals with modified genes are kindly requested to comply with related laws. Prior written consent for the purpose of use of the animals is required.
Rats purchased from Hoshino Laboratory Animals, Inc.
Diabetes・Obesity
Hos:ZFDM -Leprfa
| Source | Hoshino Laboratory Animals, Inc.(2008) |
| Gene | Leprfa |
| Coat color | Hooded |
- Use for studies: Obesity, Hyperlipidemia, Non-insulin-dependent diabetes mellitus, Diabetic nephropathy
Rats purchased Institute for Animal Reproduction
Iar:Long-Evans
| Source | Tohoku university School of Medicine(1994 or 1996) |
| Coat color | Hooded |
- Use for studies: Ophthalmology, Behavior
Gerｍ-free
F344/NSlc[GF]
| Source | Institute of Medical Science,University of Tokyo(1980) |
| Coat color | Albino |
- small in body size
- Rapid growth rate
- Low level of aggressiveness
- Easy to handle because of their gentleness
- Used for pharmacology, efficacy, and long-term carcinogenicity tests